The Fund is an actively managed exchange-traded fund (ETF) that seeks to achieve its investment objective by purchasing securities Clough Capital Partners L.P. (the Adviser), the Funds investment adviser, believes to have above-average financial characteristics, be undervalued and/or have growth potential. The Adviser identifies securities to purchase for the Fund that are U.S.-listed companies of all market capitalizations. The Funds positions are generally expected to be comprised of U.S.-listed equity securities of any market capitalization or depositary receipts, including American Depositary Receipts (ADRs), European Depositary Receipts (EDRs) and Global Depositary Receipts (GDRs). The Adviser typically looks to purchase securities of companies organized in the U.S. but doing a substantial amount of business outside the U.S. that it believes will outperform the market over the course of an entire market cycle (typically between 5 and 11 years) while maintaining overall portfolio volatility that is lower than that experienced by the broader market. The Adviser will obtain exposure to emerging markets through investments in U.S.-listed securities, including ADRs, of companies domiciled in emerging markets.