Cleveland BioLabs Announces Acceptance of Entolimod Phase 1 Study Findings for Poster Presentation at ASCO

Cleveland BioLabs, Inc. CBLI today announced that findings from a Phase 1 clinical study of entolimod (previously known as CBLB502) have been accepted for poster presentation at the 2015 annual meeting of the American Society of Clinical Oncology (ASCO), which will be held from May 29 - June 2 in Chicago, Illinois. The poster, titled: "A phase I study of the toll-like receptor 5 (TLR5) agonist, entolimod in patients with advanced cancers," will be presented by Hatoon Bakhribah, MD, a Drug Development Fellow at Roswell Park Cancer Institute, during the Developmental Therapeutics - Immunotherapy poster session on May 30, 2015, between 8 a.m. and 11:30 a.m. CDT. Entolimod is a toll-like receptor 5 (TLR5) agonist that has shown preclinical potential in the immunotherapy of cancer. Entolimod administration activates innate and adaptive immune responses and mobilizes immunocytes to organs -- such as the liver, intestine, and bladder -- that have high TLR5 expression. Enrollment in a Phase 1 open-label, dose-escalation trial of entolimod in patients with advanced cancer was completed in September 2014 at Roswell Park in the United States. The study, led by Alex Adjei, M.D., Ph.D., F.A.C.P., Chair of the Department of Medicine and Senior Vice President of Clinical Research at Roswell Park Cancer Institute, was designed to evaluate the safety, pharmacokinetic, and immunoactivation profiles of entolimod. Assessments for evidence of anticancer activity were also performed. Dosing is ongoing in a follow-on study in Moscow, Russia intended to extend the clinical observations from the higher entolimod dose levels evaluated in the Roswell Park trial.