Rosetta Genomics Announces Data Published in Leukemia Research

Rosetta Genomics Ltd.

, a leading developer and provider of microRNA-based molecular and other diagnostics, announces that data highlighting its microRNA platform technology was published in Leukemia Research in an article entitled, "microRNA signature is indicative of long term prognosis in diffuse large B cell lymphoma." The article can be accessed online at www.lrjournal.com. The study compared microRNA (miR) expression between patients with diffuse large B-cell lymphoma (DLBCL) who had a poor prognosis with those who had a favorable prognosis. DLBCL accounts for 30-40% of all adult non-Hodgkin's lymphomas and is heterogeneous in terms of clinical features and prognosis. The study group included 83 patients with DLBCL. miR signature from tissue biopsies was compared between patients who relapsed within nine months from commencement of treatment (defined as poor prognosis, n=43) and those with disease-free survival of at least five years (defined as good prognosis, n=40). RNA was analyzed using Rosetta's custom microarrays. Quantitative real-time polymerase chain reaction (qRT-PCR) was used for technical validation of microarray results. Eight miRs were found to be differently expressed between the two prognostic groups. In the poor prognosis group, hsa-miR-17-5p, hsa-miR-19b-3p, hsa-miR-20a-5p and hsa-miR-106a-5p were found to be up-regulated, while hsa-miR-150-5p, hsa-miR-342-3p, hsa-miR-181a-5p and hsa-miR-140-3p were found to be down-regulated, compared with the good prognosis group. "Our data are in agreement with previous findings showing that miR signature is predictive of prognosis for patients with DLBCL, although with different miRs achieving statistical significance," noted the study's lead author, Prof. Meir Lahav, M.D., Institute of Hematology, Davidoff Centre, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. "These are exciting data as they illustrate our proprietary platform's ability to identify microRNA signatures in hematologic malignancies that can differentiate poor and favorable prognostic groups," noted Kenneth A. Berlin, President and Chief Executive Officer of Rosetta Genomics. "Importantly, these data complement our broader commitment to expand our commercial offerings and clinical pipeline in oncology diagnostics."