Immune Design Announces Treatment of Patients With CMB305 Investigational Immuno-Oncology Agent

Immune Design

, a clinical-stage immunotherapy company focused on cancer, today announced the dosing of patients in a Phase 1b clinical trial of CMB305, a "prime-boost" immuno-oncology product candidate generated from the company's ZVexTM and GLAASTM platforms. CMB305 is the first product candidate of Immune Design's Specific Antigen approach, which is one of the company's two distinct approaches to fighting cancer. CMB305 is a novel combination product that involves the sequential dosing of two complementary agents, LV305 and G305, and is designed to synergistically induce anti-tumor cytotoxic T lymphocytes (CTLs) to target tumors that express NY-ESO-1, a tumor antigen found in a broad set of tumors. "CMB305's prime-boost approach leverages the activation of two separate arms of the patient's immune system, that when combined under this novel approach, are designed to induce a strong and long lasting anti-tumor CD8 T cell response, as well as activate other complementary immune effectors that may help to fight cancer," said Carlos V. Paya, MD, PhD, chief executive officer of Immune Design. The Phase 1b open label, multi-center trial (NCT02387125) is designed to evaluate the safety and tolerability,