Arrowhead Releases White Paper on Hepatitis B Virus and Potential RNAi Treatment

Arrowhead Research Corporation

announced today that it has released a white paper describing the health problem posed by the hepatitis B virus, the substantial unmet need for chronic HBV infected patients, and how Arrowhead's Dynamic Polyconjugate enabled RNAi therapeutic in development could potentially address deficiencies of current treatment options. HBV infection occurs primarily in hepatocytes and long-term infection causes hepatic inflammation that leads to acute and chronic hepatic dysfunction including acute hepatic failure, cirrhosis, and hepatocellular carcinoma. The DPC delivery platform is being employed for the HBV product candidate, which is supported by multiple studies including demonstration in non-human primates of safe and effective delivery of siRNA to hepatocytes and promising data generated through mouse models of HBV using a DPC formulation.