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Updated: Aug 17, 2026
SPRO Logo

Spero Therapeutics

NASDAQ:SPRO·Stock Analysis Report
Day Range
$1.21 - $1.23
Market Cap
68.90M
P/E Ratio
8.7857
Avg Value
$2.10
Year Range
$1.13 - $3.08
$1.21-$0.02 (-1.63%)
1
General Information
Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases.

The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. It is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.

2
Spero Therapeutics (SPRO) Stock Graph
3
How We Grade Spero Therapeutics (SPRO)

We grade stocks based on past performance, their future growth potential, intrinsic value, dividend history, and overall financial health.

The chart below shows how we grade Spero Therapeutics (SPRO) across the board compared to its closest peers.

4
Benzinga Edge Rankings

Benzinga Edge stock rankings give you four critical scores to help you identify the strongest and weakest stocks to buy and sell.

5
Peer Ratings

See how Spero Therapeutics compares to its peers in these key performance metrics from Benzinga Rankings.

Top Peers
Value
Quality
Growth
Momentum
Short
Medium
Long
CYPHCypherpunk Technologies
N/A
N/A
N/A
N/A
RNTXRein Therapeutics
N/A
N/A
N/A
N/A
XBITXBiotech
N/A
N/A
N/A
N/A
PMVPPMV Pharmaceuticals
N/A
N/A
N/A
N/A
Short: price trend over the last couple of months
Medium: price trend over the last couple of quarters
Long: price trend over the past year
Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
6
Valuation

Earnings History (3 years)

It is important to look at a companies earnings history to see not only if they are profitable, but if their earnings are growing.
As you can see from the chart above, SPRO's earnings have fluctuated but has increased since, this is a positive sign for the stock.
7
Past Performance
How has Spero Therapeutics (SPRO) performed over the past 5 years?

The two main factors that we consider when analyzing past performance is overall return and volatility

Using these two metrics, we can determine if this stock gave its investors enough return for the risk that they took on by owning it. This is measured by the sharpe ratio, which has been used as a primary measure of risk/reward trade-off for almost 60 years.

This ratio can be interpreted as the amount of return an investor has received for the amount of risk that they took on by owning the stock over that timeframe.

Spero Therapeutics (SPRO) sharpe ratio over the past 5 years is -0.2841 which is considered to be below average compared to the peer average of -0.2767

8
Company Financials
INCOME STATEMENT
The income statement also known as the profit and loss statement, primarily focuses on the company's revenues and expenses during a particular period.

The main purpose of an income statement is to convey details of profitability and business activities. Below, is SPRO's income statement for the previous four years along with its trailing-twelve- month profit & loss.

FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Total Revenue
0.05
0.10
0.03
0.06
0.04
Operating Revenue
0.05
0.10
0.03
0.06
0.04
Cost Of Revenue
Gross Profit
Operating Expense
0.08
0.07
0.10
0.05
0.04
Selling General And Administration
0.04
0.03
0.02
0.02
0.02
Research and Development
0.05
0.05
0.10
0.04
0.02
Operating Income
-0.03
0.03
-0.07
0.01
0.01
Net Non-Operating Interest Income Expense
0.00
0.00
0.00
0.00
0.00
Other Income Expense
-0.01
-0.01
0.00
0.00
0.00
Other Non-Operating Income Expenses
0.00
0.00
0.00
0.00
0.00
Pre-Tax Income
-0.05
0.03
-0.07
0.01
0.01
Tax Provision
Net Income
-0.05
0.02
-0.07
0.01
0.01
Net Income Common Stockholders
-0.05
0.02
-0.07
0.01
0.01
Total Operating Income As Reported
-0.04
0.02
-0.07
0.01
0.01
Total Expenses
0.08
0.07
0.10
0.05
0.04
Net Income From Continuing And Discontinued Operation
-0.05
0.02
-0.07
0.01
0.01
Normalized Income
-0.03
0.03
-0.07
0.01
0.01
Interest Income
0.00
0.00
0.00
0.00
0.00
Interest Expense
0.00
0.00
Net Interest Income
0.00
0.00
0.00
0.00
0.00
EBIT
-0.04
0.03
-0.07
0.01
0.01
EBITDA
-0.04
0.03
-0.07
0.01
0.01
Reconciled Cost Of Revenue
Reconciled Depreciation
0.00
0.00
0.00
Normalized EBITDA
-0.03
0.03
-0.07
0.01
0.01
Tax Rate For Calcs
0.00
0.00
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
0.00
BALANCE SHEET
The balance sheet is a snapshot of a companies financials during a particular period in time.

It breaks down what company owns (assets) and what a company owes (liabilities), in order to give investors an overview of its capital structure.

FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Total Assets
0.12
0.18
0.11
0.07
0.05
Current Assets
0.11
0.13
0.11
0.07
0.05
Total Non-Current Assets
0.01
0.05
0.00
0.00
0.00
Total Liabilities Net Minority Interest
0.05
0.08
0.06
0.01
0.01
Current Liabilities
0.02
0.04
0.05
0.01
0.01
Other Non-Current Liabilities
0.00
0.00
0.00
0.00
Total Equity Gross Minority Interest
0.08
0.11
0.05
0.06
0.04
Stockholders Equity
Total Capitalization
0.08
0.11
0.05
0.06
0.04
Common Stock Equity
0.08
0.11
0.05
0.06
0.04
Net Tangible Assets
0.08
0.11
0.05
0.06
0.04
Working Capital
0.09
0.09
0.06
0.06
0.04
Invested Capital
0.08
0.11
0.05
0.06
0.04
Tangible Book Value
0.08
0.11
0.05
0.06
0.04
Total Debt
0.01
0.01
0.00
0.00
0.00
Net Debt
Share Issued
0.05
0.05
0.05
0.06
0.06
Ordinary Shares Number
0.05
0.05
0.05
0.06
0.06
CASH FLOW STATEMENTS
A companies statement of cash flows gives an investor a break down of the cash inflows and outflows from a companies operations and investment activities.
FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Cash Flow from Continuing Operating Activities
-0.01
-0.03
-0.02
-0.01
0.02
Net Income from Continuing Operations
-0.05
0.02
-0.07
0.01
0.01
Depreciation and Amortization
0.00
0.00
0.00
Deferred Tax
Deferred Income Tax
Stock-Based Compensation
0.01
0.01
0.01
0.00
0.00
Other Non-Cash Items
0.00
0.00
0.00
0.00
0.00
Change in Working Capital
0.02
-0.07
0.04
-0.03
0.01
Change in Receivables
0.00
0.00
0.00
0.00
0.00
Changes in Account Receivables
Change in Inventory
Change in Payables and Accrued Expense
-0.01
0.00
0.02
-0.02
0.00
Change in Payable
0.00
0.00
0.01
-0.01
0.00
Change in Account Payable
0.00
0.00
0.01
-0.01
0.00
Change in Other Current Assets
0.00
-0.10
0.05
0.02
0.02
Change in Other Current Liabilities
0.00
0.00
0.00
0.00
0.00
Change in Other Working Capital
0.02
0.03
-0.03
-0.03
-0.02
Cash Flow from Continuing Investing Activities
0.03
0.00
Net PPE Purchase and Sale
Net Business Purchase and Sale
Purchase of Business
Net Investment Purchase and Sale
0.03
0.00
Purchase of Investment
-0.03
0.00
Sale of Investment
0.06
0.00
Net Other Investing Changes
Financing Cash Flow
-0.03
0.00
Cash Flow from Continuing Financing Activities
-0.03
0.00
Net Issuance Payments of Debt
Net Long-Term Debt Issuance
Long-Term Debt Issuance
Long-Term Debt Payments
Net Short-Term Debt Issuance
Net Common Stock Issuance
0.02
0.00
Common Stock Issuance
0.02
0.00
Common Stock Payments
Cash Dividends Paid
Net Other Financing Charges
End Cash Position
0.28
0.34
0.27
0.17
0.20
Changes in Cash
0.00
-0.03
-0.02
-0.01
0.02
Beginning Cash Position
0.28
0.38
0.30
0.18
0.18
Capital Expenditure
Issuance of Capital Stock
0.02
0.00
Issuance of Debt
Repayment of Debt
Repurchase of Capital Stock
Free Cash Flow
-0.01
-0.03
-0.02
-0.01
0.02