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Updated: Sep 27, 2026
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Silence Therapeutics

NASDAQ:SLN·Stock Analysis Report
Day Range
$10.76 - $11.26
Market Cap
694.88M
P/E Ratio
0.0000
Avg Value
$10.88
Year Range
$4.19 - $17.58
$10.80-$0.40 (-3.57%)
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General Information
Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid or siRNA.

Using its mRNAi GOLD platform, the company has generated siRNA product candidates both for its internal development pipeline as well as for out-licensed programs with third-party collaborators. Its wholly owned pipeline is focused on three therapeutic areas: cardiovascular disease, hematology, and rare diseases. The different product candidates in its pipeline are Divesiran (SLN124), a siRNA product candidate that has the potential to treat several hematological disorders; Zerlasiran (SLN360), being developed as a potential treatment to reduce cardiovascular issues; SLN-312; SLN-548; and multiple other programs.

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Silence Therapeutics (SLN) Stock Graph
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How We Grade Silence Therapeutics (SLN)

We grade stocks based on past performance, their future growth potential, intrinsic value, dividend history, and overall financial health.

The chart below shows how we grade Silence Therapeutics (SLN) across the board compared to its closest peers.

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Benzinga Edge Rankings

Benzinga Edge stock rankings give you four critical scores to help you identify the strongest and weakest stocks to buy and sell.

Momentum measures a stock's relative strength based on its price movement patterns and volatility over multiple timeframes, ranked as a percentile against other stocks.

Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
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Peer Ratings

See how Silence Therapeutics compares to its peers in these key performance metrics from Benzinga Rankings.

Top Peers
Value
Quality
Growth
Momentum
Short
Medium
Long
IRWDIronwood Pharmaceuticals
43.01
N/A
15.6
96.97
MDXGMiMedx Group
41.34
N/A
N/A
46.93
NVCTNuvectis Pharma
N/A
N/A
N/A
98.96
VSTMVerastem
N/A
N/A
N/A
94.32
Short: price trend over the last couple of months
Medium: price trend over the last couple of quarters
Long: price trend over the past year
Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
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Past Performance
How has Silence Therapeutics (SLN) performed over the past 5 years?

The two main factors that we consider when analyzing past performance is overall return and volatility

Using these two metrics, we can determine if this stock gave its investors enough return for the risk that they took on by owning it. This is measured by the sharpe ratio, which has been used as a primary measure of risk/reward trade-off for almost 60 years.

This ratio can be interpreted as the amount of return an investor has received for the amount of risk that they took on by owning the stock over that timeframe.

Silence Therapeutics (SLN) sharpe ratio over the past 5 years is -0.4914 which is considered to be below average compared to the peer average of -0.3901