- Orexigen Therapeutics, Inc. OREX shares surged 44.3 percent to $2.99 after the company announced a new ad campaign that will launch this week called 'Brains Behind Weight Loss'.
- CymaBay Therapeutics Inc CBAY shares climbed 33.7 percent to $2.54 after the company reported a licensing deal with Kowa Pharmaceuticals America, Inc. for exclusive US rights to arhalofenate.
- Evoke Pharma Inc EVOK shares jumped 27 percent to $2.63. Evoke Pharma disclosed that Phase 3 Gimoti trial failed to reach its primary endpoint. However, the company announced that 51 percent of patients responded better to Gimoti than placebo.
- Merus NV MRUS shares gained 22.9 percent to $25.90.
- PhotoMedex Inc PHMD shares rose 22.1 percent to $2.97. PhotoMedex shares have increased 10.45 percent over the past 52 weeks, while the S&P 500 index has gained 12.18 percent in the same period.
- O2Micro International Limited (ADR) OIIM shares surged 21.5 percent to $2.30 after the company revised its Q4 financial guidance. O2Micro raised its Q4 revenue guidance from $14.7 million-$15.6 million to $15.4 million-$15.9 million.
- Weight Watchers International, Inc. WTW climbed 19.2 percent to $13.21.
- ImmunoGen, Inc. IMGN shares rose 18 percent to $2.45 after gaining 1.96 percent on Tuesday.
- Shake Shack Inc SHAK gained 7.7 percent to $38.90. Shake Shack will replace Chemours in the S&P SmallCap 600 after the close of trading on January 4.
- Partner Communications Company Ltd (ADR) PTNR shares rose 6.8 percent to $5.43 after gaining 8.42 percent on Tuesday.
- Encana Corp (USA) ECA shares rose 6.2 percent to $12.68 in pre-market trading. Ecana is expecting 2017 corporate margin to be greater than $10 per barrel of oil equivalent.
- Chemours Co CC shares gained 6.2 percent to $22.53. Chemours will replace IDEXX Laboratories, Inc. IDXX in the S&P MidCap 400 after the close of trading on January 4.
- Nivalis Therapeutics Inc NVLS shares rose 5.2 percent to $2.32. Nivalis Therapeutics disclosed that it is exploring strategic alternatives for the company and has engaged Ladenburg Thalmann to act as an advisor.
- Abercrombie & Fitch Co. ANF gained 5.1 percent to $12.73. FBR Capital upgraded Abercrombie & Fitch from Underperform to Market Perform.
- Fusion Telecommunications Int'l, Inc. FSNN surged 4.7 percent to $1.52. Craig-Hallum initiated coverage on Fusion Telecommunications with a Buy rating.
- Global Blood Therapeutics Inc GBT rose 4.2 percent to $14.90. JPMorgan initiated coverage on Global Blood Therapeutics with an Overweight rating.
- Achaogen Inc AKAO rose 4.1 percent to $13.53. Leerink Swann initiated coverage on Achaogen with an Outperform rating.
- Aecom ACM gained 3.4 percent to $38.26. Baird upgraded Aecom from Neutral to Outperform.
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