18 Biggest Mid-Day Gainers For Wednesday - Agios Pharmaceuticals (NASDAQ:AGIO), Applied Optoelectronics (NASDAQ:AAOI)

Retrophin Inc RTRX shares climbed 40.8 percent to $22.97 as the company disclosed that its Phase 2 DUET study of sparsentan achieved primary efficacy endpoint.
Cogentix Medical Inc CGNT shares climbed 39.1 percent to $1.67 after the company disclosed that it has entered into a definitive agreement for a $25 million equity investment.
Agios Pharmaceuticals Inc AGIO shares climbed 22.8 percent to $45.85 as the company disclosed that its partner Celgene Corporation CELG will submit a new drug application to the FDA for enasidenib based on ongoing Phase 1/2 study.
Evoke Pharma Inc EVOK shares rose 15.4 percent to $2.10 as the company reported positive non-clinical pre-NDA meeting with the FDA related to Gimoti.
Applied Optoelectronics Inc AAOI shares gained 14.4 percent to $19.91 as the company lifted its Q3 forecast.
Malibu Boats Inc MBUU shares rose 14.3 percent to $15.90 as the company posted better-than-expected Q4 results.
Mitcham Industries, Inc. MIND shares gained 11.9 percent to $2.98. Mitcham Industries is projected to post quarterly earnings after the closing bell.
Western Digital Corp WDC shares jumped 11.6 percent to $53.08 after the company increased its earnings and revenue forecast for the first quarter.
Calavo Growers, Inc. CVGW shares gained 10.1 percent to $65.49 as the company posted upbeat Q3 results.
Elephant Talk Communications Corp ETAK shares rose 7.8 percent to $0.175. Elephant Talk signed a new strategic partnership agreement with Expeto.
Francesca's Holdings Corp FRAN rose 7.1 percent to $14.98 after the company reported better-than-expected Q2 results and lifted its FY16 guidance.
Allegiant Travel Company ALGT shares gained 6.8 percent to $144.16 after the company disclosed preliminary passenger traffic results for August.
Ligand Pharmaceuticals Inc. LGND rose 6.5 percent to $115.11. Deutsche Bank upgraded Ligand from Sell to Hold.
Organovo Holdings Inc ONVO shares gained 6.1 percent to $4.18 after the company reported the initiation of commercial contracting for its ExVive Human Kidney tissue.
Chipotle Mexican Grill, Inc. CMG shares rose 5.8 percent to $438.02 after Bill Ackman’s Pershing Square disclosed a 9.9 percent stake in the company. It should be noted that the 2,882,463 shares position has an activist nature, as suggested by the 13D SEC filing.
Bioline RX Ltd BLRX shares rose 5 percent to $0.946 as the company announced a collaboration with Genentech to investigate combination of BL-8040 with Atezolizumab.
Progenics Pharmaceuticals, Inc. PGNX rose 2.5 percent to $6.31. Valeant Pharmaceuticals Intl Inc and Progenics reported the U.S. commercial launch of FDA-approved Relistor tablets.
Valeant Pharmaceuticals Intl Inc VRX shares rose 2.3 percent to $30.16 following Relistor tablets launch news.

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