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Eli Lilly and Company
announced that radiographic results from a long-term extension study of baricitinib, RA-BEYOND, and patient-reported outcomes data from baricitinib's phase 3 global studies will be presented, along with other phase 2b and preclinical studies, at the Annual European Congress of Rheumatology (EULAR 2016) in London, June 8-11, 2016.
"We look forward to presenting new data from our immunology portfolio at the Annual European Congress of Rheumatology (EULAR 2016)," said J. Anthony Ware, M.D., senior vice president, product development, Lilly Bio-Medicines. "Lilly is committed to developing the next generation of treatments, especially for people with rheumatoid arthritis and psoriatic arthritis because these patients deserve new alternative treatment options."
Highlighted presentations and posters include:
Baricitinib Data
Thursday, June 9, 2016, 11:45am - 1:30pm BST – POSTER PRESENTATIONS
Safety Profile of Baricitinib in Patients with Active RA: An Integrated Analysis (Presenting Author: Smolen, J.) Abstract Number: THU0166
Baricitinib Inhibits Radiographic Progression of Structural Joint Damage at 1 Year in Patients with Rheumatoid Arthritis (RA) and An Adequate Response to csDMARDs (Presenting Author: van der Heijde, D.) Abstract Number: THU0168
Ex Vivo Functional Comparison of Baricitinib and Tofacitinib for Cytokine Signaling in Human Leukocyte Subpopulations (Presenting Author: McInnes, I.) Abstract Number: THU0182
Response to Baricitinib at 4 Weeks Predicts Response at 12 and 24 Weeks in Patients with Rheumatoid Arthritis: Results from Two Phase 3 Studies (Presenting Author: Weinblatt, M.) Abstract Number: THU0193
Baricitinib Effects on Lipid and NMR-Measured Lipoprotein Profiles in a Phase 3 Study in Patients with Rheumatoid Arthritis (Presenting Author: Taylor, P.) Abstract Number: THU0198
Weak Correlation Between a Multi-Biomarker Disease Activity Score and Clinical Response with Baricitinib in a Phase 2b Study in Rheumatoid Arthritis (Presenting Author: Fleischmann, R.) Abstract Number: THU0201
Characterization of Changes in Lymphocyte Subsets in Baricitinib-Treated Patients with Rheumatoid Arthritis in a Phase 3 Study (RA-BEAM) (Presenting Author: Tanaka, Y.) Abstract Number: THU0209
Patient-Reported Outcomes from a Phase 3 Study of Baricitinib Versus Placebo or Adalimumab in Patients with Active Rheumatoid Arthritis and an Inadequate Response to Background Methotrexate Therapy (Presenting Author: Keystone, E.) Abstract Number: THU0609
Work Productivity and Daily Activity in Patients with Rheumatoid Arthritis in Four Phase 3 Randomized Clinical Trials of Baricitinib (Presenting Author: Smolen, J.S.) Abstract Number: THU0617
Patient-Reported Outcomes from a Phase 3 Study of Baricitinib in Patients with Early Rheumatoid Arthritis who had Received Limited or no Treatment with Disease-Modifying Anti-Rheumatic Drugs (Presenting Author: Schiff, M.) Abstract Number: THU0623
Friday, June 10, 2016, 11:10am - 11:20am BST – ORAL PRESENTATION
Baricitinib Dose Step-Down Following Disease Control in Patients with Rheumatoid Arthritis (Presenting Author: Takeuchi, T.) Abstract Number: OP0228
Friday, June 10, 2016, 11:15am - 1:30pm BST – POSTER PRESENTATION
Influence of Route of Administration/Drug Formulation and Other Factors on Compliance with Treatment in Rheumatoid Arthritis and Dyslipidaemia (Presenting Author: Fautrel, B.) Abstract Number: FRI0565
Ixekizumab Data
Thursday, June 9, 2016, 11:45am - 1:30pm BST – POSTER PRESENTATIONS
Ixekizumab Provides Improvements Through 52 Weeks in Physical Function, Quality of Life, and Work Productivity in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis (Gottlieb, A.B.) Abstract Number: THU0430
Ixekizumab Provides Sustained Improvement up to 52 Weeks of Disease Activity as Assessed by Composite Measure Scores in Biologic Disease-Modifying Antirheumatic Drug (bDMARD)-Naive Patients with Active Psoriatic Arthritis (Coates, L.C.) Abstract Number: THU0440
Effect of Concomitant Conventional Disease-Modifying Antirheumatic Drugs (DMARDs) on the Efficacy and Safety of Ixekizumab in Biologic DMARD-Naive Patients with Active Psoriatic Arthritis (Presenting Author: Coates, L.C) Abstract Number: THU0441
Friday, June 10, 2016, 10:30am - 10:40am BST – ORAL PRESENTATION
Efficacy and Safety of Ixekizumab in Patients with Active Psoriatic Arthritis: 52 week Results from a Phase 3 Study (SPIRIT-P1) (Presenting Author: Mease, P.J.) Abstract Number: OP0109
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