Benzinga's Top #PreMarket Losers

fell 57 percent to $6.85 in pre-market trading after the company reported a patient death in clinical update on Beloranib.

shares tumbled 7.58 percent to $2.44 in pre-market trading after gaining 28.16 percent on Tuesday.

shares dipped 7.30 percent to $17.64 in pre-market trading as the company reported an offering for 51 million shares of common stock.

shares fell 2.95 percent to $4.28 in pre-market trading.

, TerraForm Global and Renova Energia reported the termination of previously-disclosed deals. SunEdison reported that the $250 million securities purchase deal with Light Energia to purchase 16 stake in Renova has ben terminated. Goldman Sachs downgraded TerraForm Global from Neutral to Sell.

shares declined 2.84 percent to $8.89 in pre-market trading after jumping 32.61 percent on Tuesday.