Intercept Presents New Data Analyses on Non-Invasive Liver Testing From FLINT Trial of Obeticholic Acid in Nonalcoholic Steatohepatitis at AASLD 2015

Intercept Pharmaceuticals, Inc.

announced Saturday, new results from the first non-invasive evaluation of liver fibrosis in patients from the FLINT trial of obeticholic acid (OCA) for the treatment of nonalcoholic steatohepatitis (NASH). The data will be presented on November 17 at the American Academy for the Study of Liver Diseases (AASLD) Annual Meeting (The Liver Meeting®) in an oral presentation entitled, "Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial" at 12:15 p.m. PT in the Moscone Center, Room 2016. In the FLINT trial, treatment with once daily 25 mg OCA was shown to reverse fibrosis in a significant proportion of biopsy-proven NASH patients, as observed by repeat liver biopsy at the end of the double-blind treatment phase (week 72). The post-hoc analysis to be presented at AASLD evaluated the early predictive value of three known non-invasive fibrosis tests in identifying patients who experienced improvement in fibrosis: FIB-4, APRI and NFS. Each was assessed at baseline and over the course of