Benzinga's Top #PreMarket Losers

shares declined 20.24 percent to $17.90 in pre-market trading. Horizon Pharma responded to a lawsuit filed by Express Scripts Holding Company

and recent allegations.

shares fell 5.70 percent to $20.00 in pre-market trading after gaining 5.47 percent on Tuesday.

shares tumbled 5.45 percent to $44.44 in pre-market trading after the company lowered its full-year earnings forecast and rejected the REIT formation.

shares dipped 5.06 percent to $63.20 in pre-market trading after the company commenced an underwritten public offering of 5 million of its common stock.

fell 1.90 percent to $35.05 in pre-market trading after the company priced 4.033 million share offering at $34.50 per share.