AcelRx Pharmaceuticals Presents Data from Phase 3 Clinical Trials Evaluating the Safety and Efficacy of Zalviso in Obese Surgical Patients

AcelRx Pharmaceuticals, Inc. ACRX will be presenting at ObesityWeek 2015 an analysis from three Phase 3 studies showing that Zalviso™ (sufentanil sublingual tablet system 15 mcg) provides a faster onset of pain relief in obese (BMI ≥ 30 kg/m2) post-surgical patients than intravenous (IV) patient-controlled analgesia (PCA) with morphine. Specifically, patients who self-administered Zalviso experienced statistically significantly improved pain relief when compared to self-administered IV morphine as measured by pain intensity difference to baseline (PID).  Significant differences in PID were observed as early as 45 minutes after the first dose (p<0.05), a trend that continued until six hours after the initial dose (p<0.001), after which time PID scores equilibrated between the two groups. "Both of our lead products, Zalviso and ARX-04 (a double-strength dose of sublingual sufentanil 30 mcg administered by a nurse) benefit from sufentanil's lipophilic nature," said Dr. Pamela Palmer, AcelRx Co-founder and Chief Medical Officer.  "Lipophilic, or fat-soluble drugs, typically produce rapid drug uptake from mucosal tissues into the plasma and then into the brain, promoting minimal delay between dosing and See full press release