Celyad Awarded US Patent Covering Allogeneic CAR-T Cells Modified to Reduce Immunogenicity

Celyad CYAD today announced the issuance of United States Patent No. 9,181,527 ("US Patent 9,181,527") relating to allogeneic human primary T-Cells that are engineered to be T-Cell Receptor (TCR)-deficient and express a Chimeric Antigen Receptor (CAR). The US 9,181,527 Celyad Allogeneic Patent significantly strengthens Celyad's patent portfolio in the CAR T-Cell field and its leadership in engineered cell therapy since the granted product claims are not limited to specific CARs or specific methods of generating allogeneic CAR T-Cells, such as genome editing or genetic engineering. The patented products are applicable for use in treating various human disease conditions such as cancer, chronic infectious diseases, and autoimmunity. Allogeneic technology has the potential to broaden the therapeutic applications of CAR T-Cell immunotherapies by enabling the development and manufacturing of "off-the-shelf" treatments. Dr. Christian Homsy, CEO of Celyad, commented: "We are pleased to have obtained the 9,181,527 Patent from the United States Patent and Trademark Office (USPTO) for allogeneic T-Cells engineered to express a CAR, and we are pursuing patents in other geographies See full press release