Genentech Presents Positive Results from Pivotal Study of Atezolizumab in Specific Type of Advanced Bladder Cancer at 2015 ECC

Genentech, a member of the Roche Group

, today announced early results from a pivotal Phase II study, IMvigor 210, of the investigational cancer immunotherapy atezolizumab (anti-PDL1; MPDL3280A) in people with locally advanced or metastatic urothelial carcinoma (mUC). The study showed that atezolizumab shrank tumors (objective response rate, ORR) in 27 percent of people with mUC whose disease had medium and high levels of PD-L1 expression and worsened after initial treatment. Ninety-two percent of people who responded to atezolizumab continued to respond when the results were assessed. Median duration of response was not yet reached. Adverse events were consistent with those observed in previous studies. "These results may represent