Benzinga's Top #PreMarket Losers

Norfolk Southern Corporation NSC slipped 5.61% to $98.99 in pre-market trading after the company issued a weak outlook for the first quarter. Martin Marietta Materials Inc. MLM shares fell 5.17% to $130.86 in pre-market trading after dropping 0.39% on Monday. Arrowhead Research Corp. ARWR shares declined 3.87% to $7.69 in pre-market trading. Jefferies downgraded Arrowhead Research from Buy to Hold. CSX Corp. CSX fell 2.66% to $32.20 in pre-market trading. The railroad company is projected to post quarterly results today. Amarin Corporation plc AMRN shares dropped 1.18% to $2.52 in pre-market after falling 1.54% on Monday.