Acceleron Pharma Inc. XLRN, a clinical stage biopharmaceutical
company focused on the discovery, development and commercialization of novel
protein therapeutics for cancer and rare diseases, today announced results
from an interim report for a two-part clinical study sponsored by the
Gynecology Oncology Group evaluating dalantercept as monotherapy in patients
with recurrent or persistent epithelial ovarian cancer. The study design
required at least 7 of 30 patients enrolled in part one of the study to be
progression free for greater than six months in order to trigger the
enrollment of approximately an additional 30 patients for part two of this
study. In part one of the study, 6 patients were progression free without
receiving non-protocol therapy for greater than six months. Based on these
results, patients will not be enrolled in the second part of the trial.
“We are conducting internally run clinical studies in those indications where
the supporting science tells us that dalantercept has the best chance of
benefitting patients, such as our ongoing studies of dalantercept used in
combination with approved angiogenesis inhibitors to treat patients with
kidney and liver cancer. However, we also welcome collaborations with
investigators and collaborative groups to conduct externally sponsored
clinical trials, such as this monotherapy ovarian cancer study, that
complement our core development programs. We believe this is an efficient
approach to broadly explore the potential benefits of dalantercept in a
variety of cancers,” said John Knopf, Ph.D., Chief Executive Officer of
Acceleron.
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