Shire Issues Statement Regarding Media Speculation

Shire plc ("Shire" or the "Company")

notes the Bloomberg article this afternoon. Shire confirms it has held a meeting with representatives of AbbVie. This statement is being made by Shire without the prior agreement or approval of AbbVie. A further update will be made when appropriate. Shareholders are strongly advised to take no action in relation to AbbVie's proposal. There can be no certainty that any firm offer will be made nor as to the terms on which any firm offer might be made.