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Shire Issues Statement Regarding Media Speculation

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Shire plc ("Shire" or the "Company") (NASDAQ: SHPG) notes the
Bloomberg article this afternoon. Shire confirms it has held a meeting with
representatives of AbbVie.

This statement is being made by Shire without the prior agreement or approval
of AbbVie.

A further update will be made when appropriate. Shareholders are strongly
advised to take no action in relation to AbbVie's proposal. There can be no
certainty that any firm offer will be made nor as to the terms on which any
firm offer might be made.

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