Benzinga's Top #PreMarket Gainers

MannKind MNKD shares jumped 98.51% to $7.98 in pre-market trading after the company confirmed that the FDA Advisory Committee recommended the approval of the company's diabetes drug AFREZZA. Envivio ENVI surged 22.73% to $4.05 in pre-market trading fter the company reported that it was powering live HD sports channels on Apple TV in Europe. Ku6 Media Co KUTV shares gained 7.33% to $3.22 in the pre-market after jumping 42.86% on Tuesday. Intuitive Surgical ISRG shares gained 4.31% to $514.88 after climbing 12.70% on Tuesday. JMP Securities upgraded the stock from Market Underperform to Market Outperform and lifted the price target from $320.00 to $700.00.