EntreMed Presents Data from Preclinical Study for ENMD-2076 in Triple-Negative Breast Cancer

EntreMed

announced today the presentation of preclinical data from a study to assess the role of p53 family tumor suppressors in mediating response to ENMD-2076 in triple-negative breast cancer (TNBC).  The study was led by Dr. Jennifer R. Diamond of University of Colorado and the results were presented at the AACR-NCI-EORTC International Conference being held this week in Boston, Massachusetts. (Logo: http://photos.prnewswire.com/prnh/20010620/ENMDLOGO ) Dr. Diamond commented, "The purpose of this study is to utilize TNBC cell line gene knockdown models to investigate further the role of p53 and p73 in mediating sensitivity to ENMD-2076.  Data from the study demonstrate that ENMD-2076 exhibited robust anticancer activity in both p53 mutated and p53 wild type (WT) cell lines. The data also illustrate that both p53 and p73 mediate sensitivity to ENMD-2076 in p53 WT TNBC, while p73 is essential for induction of senescence following exposure to ENMD-2076, providing support on the development of predictive biomarkers of response to ENMD-2076 in p53 mutated TNBC currently underway." Ken K. Ren, Ph.D, EntreMed's Chief Executive Officer, commented, "ENMD-2076 is currently in Phase 2 clinical trials