BG Medicine, Inc.
BGMD, a diagnostics company focused on the development and
commercialization of novel cardiovascular tests, announced today the
publication of two studies demonstrating the clinical utility of repeated
galectin-3 testing as a tool in the assessment of patients with heart failure.
The studies, which together involved more than 3,300 subjects, demonstrate
that periodic evaluation of galectin-3 levels can help clinicians identify
those at greater risk of unplanned hospital admission and cardiovascular
morbidity and mortality.
The first study, published online ahead of print in the current issue of
Circulation Heart Failure [1], demonstrated that patients who experienced
increases in their galectin-3 levels in excess of 15% over a period of three
to six months had nearly double the risk of subsequent unplanned hospital
admissions and mortality relative to patients who did not experience changes
in their galectin-3 levels over the same time period. This increased risk was
found to be independent of other important risk factors in heart failure,
including cardiac function, renal function, age, and levels of NT-proBNP.
The second study, published online ahead of print in the European Journal of
Heart Failure [2], demonstrated that patients who experienced increases in
galectin-3 levels over a period of four months were at significantly increased
risk of subsequent unplanned hospital admissions for heart failure, first
morbid event, and mortality. The increased risk associated with elevations in
galectin-3 was found to be independent of all other baseline heart failure
risk factors considered. Importantly, this increased risk associated with
galectin-3 elevation was also demonstrated to be independent of, and additive
to, concomitant changes in other important heart failure risk factors,
including cardiac structure, renal function, blood pressure, heart rate,
NT-proBNP levels, and other clinical patient parameters.
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