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Zipcar (NASDAQ: ZIP) shares jumped 47.82% to $12.18 in pre-market trading. Avis Budget Group (NASDAQ: CAR) announced its plans to buy Zipcar for $500 million.

Synergy Pharmaceuticals (NASDAQ: SGYP) surged 15.81% to $6.08 in the pre-market session. Synergy Pharma reported positive results from Plecanatide Phase IIb/III trial in patients with Chronic Idiopathic Constipation.

James River Coal Co (NASDAQ: JRCC) shares rose 9.35% to $3.51 in the pre-market trading. James River Coal shares have dropped 58.15% over the past 52 weeks, while the S&P 500 index has gained 11.68% in the same period.

Neutral Tandem (NASDAQ: IQNT) gained 8.95% to $2.80 in the pre-market session. Neutral Tandem's PEG ratio is 1.35.

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