Benzinga's Top Pre-Market Losers

VeriFone Systems

shares fell 6.65% to $31.02 in the pre-market trading. VeriFone reported an 86% drop in its fiscal fourth-quarter profit and issued downbeat first-quarter forecast. Isis Pharmaceuticals

shares dropped 9.47% to $8.70 in pre-market trading. Isis Pharmaceuticals and Genzyme reported that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a negative opinion for its marketing authorization application for KYNAMRO. Clearwire

dipped 3.16% to $3.06 in the pre-market session. Sprint Nextel

is offering $2.90 per share to acquire the rest of Clearwire. Apple

dipped 1.92% to $519.50 in the pre-market session. Apple's trailing-twelve-month ROA is 23.61%.