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VeriFone Systems (NYSE: PAY) shares fell 6.65% to $31.02 in the pre-market trading. VeriFone reported an 86% drop in its fiscal fourth-quarter profit and issued downbeat first-quarter forecast.

Isis Pharmaceuticals (NASDAQ: ISIS) shares dropped 9.47% to $8.70 in pre-market trading. Isis Pharmaceuticals and Genzyme reported that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a negative opinion for its marketing authorization application for KYNAMRO.

Clearwire (NASDAQ: CLWR) dipped 3.16% to $3.06 in the pre-market session. Sprint Nextel (NYSE: S) is offering $2.90 per share to acquire the rest of Clearwire.

Apple (NASDAQ: AAPL) dipped 1.92% to $519.50 in the pre-market session. Apple's trailing-twelve-month ROA is 23.61%.

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