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Vertex, JNJ's Janssen Enter Agreement for Phase 2 Hepatitis C Study

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Vertex
Pharmaceuticals Incorporated (NASDAQ: VRTX) today announced that it
has entered into a non-exclusive collaboration with Johnson & Johnson's (NYSE: JNJ) Janssen
Pharmaceuticals, Inc. to conduct a Phase 2 proof-of-concept study of an
all-oral regimen for the treatment of hepatitis C containing Vertex's
nucleotide analogue hepatitis C virus (HCV) polymerase inhibitor VX-135
and Janssen's protease inhibitor simeprevir (TMC435). As part of the
collaboration, Janssen will conduct a drug-drug interaction study with
VX-135 and simeprevir to support the planned initiation of a Phase 2
proof-of-concept study in early 2013, pending discussions with
regulatory authorities. The Phase 2 study is expected to evaluate
safety, tolerability and viral cure rates using a 12-week combination of
VX-135 and simeprevir. The companies will jointly fund development

See full press release

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