Anavex rapidly advances ANAVEX 2-73 for Alzheimer's disease, Phase I clinical trial progressing well

Anavex Life Sciences Corp. ("Anavex") (OTC: AVXL) has commenced the 30 mg dose step in its ongoing Phase I clinical trial to evaluate ANAVEX 2-73, the company's lead drug candidate for Alzheimer's disease. This is the third of six potential dose steps and follows the successful completion of the 1 mg and 10 mg dosing rounds. There have been no adverse effects recorded after the administration of ANAVEX 2-73 at the doses studied to date.

Trial participants are receiving single, ascending oral doses of ANAVEX 2-73 with one group potentially advancing to a maximum single oral dose of 240 mg. To that end, the ANAVEX 2-73 Phase I trial is rapidly and positively advancing.

Positive safety data at lower doses has so far enabled the company to skip one higher dosing step and increase the amount being administered by ten times, from 1 mg to 10 mg, instead of from 1mg to 5mg. This recommendation was unanimously recommended by the Safety Review Committee for ANAVEX 2-73 following their evaluation of the available safety data from the first group of healthy human volunteers in the initial dose step.