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Bluebird's Encouraging Myeloma Data Not Enough For Cantor To Lift Its Sell Rating

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Bluebird's Encouraging Myeloma Data Not Enough For Cantor To Lift Its Sell Rating
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Bluebird bio Inc (NASDAQ: BLUE) announced positive early data from its ongoing open-label Phase 1 CRB-401 study with its CAR T candidate, bb2121, in patients with relapsed and/or refractory multiple myeloma.

Although the initial early data is encouraging, there are potential risk of CRS [cytokine release syndrome] at higher doses, Cantor Fitzgerald’s Elemer Piros said in a report.

Piros reiterated a Sell rating on Bluebird, with a price target of $37, commenting that the stock appeared overvalued “based on our valuation of the company's programs.”

Encouraging Myeloma Data

Early results indicated that two of nine patients achieved stringent complete responses [sCR] at a dose of 15x107 cells, encompassing 4-6 months. The initial data improves upon results that had been achieved in a previous study, led by the National Cancer Institute, of a separate anti-BCMA [B-cell maturation antigen] CAR T candidate, Piros stated.

“Safety profile for bb2121 demonstrated no signs of serious Grade 3 neurotoxicities [or CRS] at currently tested doses,” the analyst wrote. “Additional data at later time points and from the high dose of 80x107 “could provide additional clarity on a dose response, but we also remain focused any potential risk of CRS at higher doses.”

Bluebird's product candidates include Lenti-D, which is in a pivotal clinical study for the treatment of cerebral adrenoleukodystrophy; and LentiGlobin, which is in clinical studies for the treatment of thalassemia major and severe sickle cell disease.

The stock traded up 26 percent in Thursday's pre-market session.

Latest Ratings for BLUE

DateFirmActionFromTo
Nov 2016BMO CapitalInitiates Coverage OnMarket Perform
Oct 2016Cantor FitzgeraldDowngradesHoldSell
Sep 2016Maxim GroupMaintainsBuy

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Posted-In: Cantor FitzgeraldAnalyst Color Biotech Short Ideas Reiteration Analyst Ratings Trading Ideas General Best of Benzinga

 

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