Synergy's Safety Profile Should Boost Trulance Uptake, Takeover Prospects Remain Favorable


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Rodman & Renshaw reiterated its Buy rating on Synergy Pharmaceuticals Inc (NASDAQ:SGYP), saying the company’s “best-in-class” safety profile should boost the commercial launch of Trulance for the treatment of chronic idiopathic constipation (CIC).

Trulance

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“Discontinuation rates were low among patients given both drug and placebo (4 percent vs. 2 percent, respectively) and the most common discontinuation-causing event was diarrhea (2 percent for Trulance vs. 0.5 percent in placebo),” analyst Raghuram Selvaraju wrote in a note.

Meanwhile, Synergy is slated to kick off the Trulance launch campaign within the next couple of weeks, and will launch with a wholesale acquisition cost (WAC) of $353.48, effectively at parity with Linzess.

Selvaraju expects 2017 revenue of $53.6 million and $362 million in Trulance sales in 2018. The analyst also projects Synergy could turn sustainably profitable in early 2018.

Related Link: Takeda's Speculative Interest In Synergy Soothes Stomach Pains; Canaccord Says Buy


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The analyst also pointed out that investors should note that Trulance could be approved for treatment of IBS-C by the end of 2017 or early in 2018, assuming sNDA submission later this month and a statutory 10-month review period.

M&A Activity Backdrop

On the M&A front, Selvaraju the acquisition prospects for Synergy remain favorable and named Takeda Pharmaceutical Co Ltd (ADR) (OTC:TKPYY), AstraZeneca plc (ADR) (NYSE:AZN), Novartis AG (ADR) (NYSE:NVS) and Shire PLC (ADR) (NASDAQ:SHPG) as potential suitors.

“From our perspective, Synergy fits the bill of a favorable target in having: (1) positive safety and efficacy data from large, well-controlled clinical trials; (2) an approved drug with a validated mechanism of action; and (3) a significant customer base,” Selvaraju highlighted.

The analyst noted that the recent Johnson & Johnson (JNJ)’s acquisition of the Swiss biotech firm Actelion for $30 billion suggests that Synergy could be acquired at a favorable price.

Selvaraju added that Synergy could fetch a favorable price in the event of a takeover, “given the paucity of acquisition targets for large-cap pharmaceutical firms that possess the characteristics Synergy currently displays.”

At last check, shares of Synergy had fallen 3.06 percent to $5.51. Selvaraju has a price target of $18.


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Posted In: Analyst ColorBiotechNewsHealth CarePrice TargetReiterationFDAM&AAnalyst RatingsMoversGeneralRaghuram SelvarajuRodman & Renshaw