Ensysce Biosciences' Newly Formulated Oxycodone Product Shows Resistance To Tampering, Abuse


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  • Ensysce Biosciences Inc (NASDAQ:ENSCannounced topline results from a human abuse potential (HAP) study for PF614. 
  • PF614 is a new class of analgesia, a Trypsin Activated Abuse-Protected (TAAP) oxycodone product. 
  • The HAP study was designed to test if known recreational drug users "liked" the product and is critical for new drugs in this class. 
  • The primary measure in this study, "drug liking," is known to correlate with a drug's potential for abuse.
  • In the study, PF614 powder produced significantly lower peak "drug liking" when compared with intranasal crushed IR oxycodone.
  • Furthermore, in the first-period analysis of initial impressions of each drug, a similarly strong difference was noted between PF614 (n=8) and crushed IR oxycodone (n=10), even with this smaller cohort of subjects.
  • Related: Ensysce Biosciences, Quotient Partner To Work On Novel Opioid To Prevent Abuse and Overdose.
  • Statistically significant differences in peak effects (Emax) between PF614 and crushed IR oxycodone intranasal were also demonstrated for the secondary endpoint of "take drug again," where PF614 produced only 27% as high an Emax score as crushed oxycodone among recreational drug users.
  • Price Action: ENSC shares are up 11.10% at $3.45 session on the last check Monday.

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