Imara To Start Testing Tovinontrine In Heart Failure Patients


20-Year Pro Trader Reveals His "MoneyLine"

Ditch your indicators and use the "MoneyLine". A simple line tells you when to buy and sell without the guesswork. It’s a line on a chart that’s helped Nic Chahine win 83% of his options buys. Here's how he does it.


The FDA signed off Imara Inc's (NASDAQ:IMRA) investigational new drug (IND) application for tovinontrine (IMR-687) in heart failure with preserved ejection fraction (HFpEF).

  • The Company plans to initiate a Phase 2 trial in Q2 of 2022 to evaluate tovinontrine in patients 45 years of age or older with persistent HFpEF symptoms.
  • The Phase 2 HFpEF trial will be a randomized, placebo-controlled study of approximately 170 patients. Trial subjects will be dosed for 16 weeks. 
  • The primary endpoint will be a change in NT-proBNP, with secondary endpoints that include safety and tolerability and quality of life measures. 
  • Exploratory measures include a clinical composite score, a 6-minute walk test, and cardiac structure & function evaluation.
  • Related: Imara Changes Primary Endpoint In Mid-Stage Sickle Cell Disease Trial.
  • Tovinontrine is a highly selective and potent small-molecule inhibitor of phosphodiesterase-9 (PDE9). 
  • PDE9 selectively degrades cyclic guanosine monophosphate (cGMP), an active signaling molecule that plays a role in vascular biology and hemoglobin production. 
  • Price Action: IMRA shares are down 5.10% at $1.49 during the market session on the last check Tuesday.

20-Year Pro Trader Reveals His "MoneyLine"

Ditch your indicators and use the "MoneyLine". A simple line tells you when to buy and sell without the guesswork. It’s a line on a chart that’s helped Nic Chahine win 83% of his options buys. Here's how he does it.


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