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The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines) has been updated for breast cancer treatment and includes two essential changes for Puma Biotechnology Inc (NASDAQ:PBYI) Nerlynx (neratinib).
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- The first update added Nerlynx to the body of the guidelines for treating adjuvant HER2-positive Breast Cancer, with a recommendation for considering extended adjuvant neratinib for patients with HR-positive, HER2-positive disease with a perceived high risk of recurrence.
- The second update involved the inclusion of dose escalation to improve the tolerability of neratinib in the treatment of adjuvant HER2-positive Breast Cancer.
- Related: Puma Biotech's Neratinib Fails To Extend Overall Survival In Brain Cancer Trial.
- Up to 20% of patients with breast cancer tumors over-express the HER2 protein (HER2-positive disease), and in the ExteNET study, 57% of patients were found to have hormone-receptor-positive tumors.
- HER2-positive breast cancer is often more aggressive than other types of breast cancer, increasing the risk of disease progression and death.
- Price Action: PBYI shares are trading 9.16% higher at $2.86 during the premarket session on the last check Thursday.
Crypto Whales Are Loading Up — Are You?
New research shows the biggest crypto buyers are back. And this time? They could hold for the possibility that Bitcoin will surpass $100,000 in 2024. You don’t want to miss the next massive crypto bull run like we saw in 2020 and 2021. To know exactly what’s going on and what to buy… Get Access To Benzinga’s Best Crypto Research and Investments For Only $1.