Travere Posts Topline Data For Pegtibatinase In patients With Rare Metabolic Disorder


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Travere Therapeutics Inc (NASDAQ:TVTXreported topline results from the ongoing Phase 1/2 COMPOSE Study of pegtibatinase for classical homocystinuria (HCU). 

  • There were no discontinuations due to treatment-related adverse events. 
  • One serious adverse event, moderate acute urticaria (hives), was categorized to be likely related to pegtibatinase treatment but did not lead to treatment discontinuation and resolved following a single dose interruption.
  • Pegtibatinase demonstrated dose-dependent reductions in tHcy during the 12 weeks of treatment.
  • At the two highest doses, pegtibatinase appeared to reduce tHcy regardless of starting baseline tHcy levels or background therapy.
  • In the highest dose cohort to date of 1.5mg/kg BIW, pegtibatinase resulted in rapid and sustained reductions in tHcy, resulting in a maintenance of tHcy below a clinically meaningful threshold of 100 μmol from week 2 through week 12 of treatment.
  • In the 1.5mg/kg BIW dose cohort, treatment with pegtibatinase resulted in a mean relative reduction from baseline of 55.1%, compared to a decrease of 4.8% for all patients receiving placebo in the study.
  • Related Link: See Why Travere Therapeutics Stock Moving Higher On Tuesday.
  • Price Action: TVTX shares are down 4.17% at $25.25 during the market session on the last check Wednesday.

27% profits every 20 days?

This is what Nic Chahine averages with his options buys. Not selling covered calls or spreads... BUYING options. Most traders don't even have a winning percentage of 27% buying options. He has an 83% win rate. Here's how he does it.


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