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Ventyx Biosciences Inc (NASDAQ:VTYX) released results from the Phase 2 trial of VTX958 in patients with moderate to severe plaque psoriasis.
The Phase 2 SERENITY trial of VTX958 was a 16-week, randomized, double-blind, placebo-controlled, dose-ranging trial evaluating the efficacy and safety of four oral doses of VTX958 (50 mg BID, 300 mg QD, 225 mg BID, and 300 mg BID).
The primary endpoint was the proportion of participants achieving a 75% reduction in the Psoriasis Area and Severity Index (PASI 75) at Week 16.
Both high doses of VTX958 (225 mg BID and 300 mg BID) achieved statistical significance on the primary endpoint and all key secondary endpoints at Week 16. No drug-related serious adverse events were observed.
Although the trial achieved its primary endpoint, the magnitude of efficacy observed did not meet the internal target, the company said.
Ventyx Biosciences also noted that the results do not support further development of VTX958 in the highly competitive psoriasis and psoriatic arthritis indications.
Accordingly, the company said it will terminate ongoing activities in the Phase 2 plaque psoriasis trial effective immediately.
Based on these results, Ventyx Biosciences has also elected to terminate the ongoing Phase 2 trial of VTX958 in psoriatic arthritis.
The ongoing Phase 2 trial of VTX958 in Crohn's disease will continue to enroll, and plans to conduct an interim efficacy analysis in the first quarter of 2024.
Price Action: VTYX shares are down 78.70% at $3.00 during the premarket session on the last check Tuesday.
27% profits every 20 days?
This is what Nic Chahine averages with his options buys. Not selling covered calls or spreads... BUYING options. Most traders don't even have a winning percentage of 27% buying options. He has an 83% win rate. Here's how he does it.
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