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- Olema Pharmaceuticals Inc (NASDAQ:OLMA) announced preliminary clinical results from a Phase 1/2 study of OP-1250, a complete estrogen receptor (ER) antagonist (CERAN) and selective ER degrader (SERD) for metastatic breast cancer.
- Across 68 patients at 60 mg and 120 mg once daily oral dosing, OP-1250 was well tolerated with attractive pharmacokinetics (PK) and drug exposure levels approximately 20 times that of fulvestrant at the 120 mg dose.
- Related: After Denying Data Leak, Olema Shares First Data For Lead Program In Breast Cancer Patients.
- OP-1250 demonstrated strong anti-tumor activity and durable benefit, with 41% of patients seeing reductions in target tumor lesions and six partial responses (4 confirmed and 2 unconfirmed) out of 57 efficacy-evaluable patients.
- Treatment with OP-1250 was well tolerated at both the 60 mg and 120 mg dose levels with no dose-limiting toxicities.
- The company will present preliminary Phase 1b dose escalation study data in combination with palbociclib, in late 2022.
- Olema plans to initiate a pivotal Phase 3 monotherapy study in the second/third-line setting in mid-2023.
- Price Action: OLMA shares closed at $3.57 on Tuesday.
Crypto Whales Are Loading Up — Are You?
New research shows the biggest crypto buyers are back. And this time? They could hold for the possibility that Bitcoin will surpass $100,000 in 2024. You don’t want to miss the next massive crypto bull run like we saw in 2020 and 2021. To know exactly what’s going on and what to buy… Get Access To Benzinga’s Best Crypto Research and Investments For Only $1.
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