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- The FDA approved Heron Therapeutics Inc's (NASDAQ:HRTX) Aponvie (aprepitant) injectable emulsion for intravenous use for the prevention of postoperative nausea and vomiting (PONV) in adults.
- Aponvie is the first and only IV formulation of aprepitant for PONV prevention.
- Aponvie is provided in a single-dose vial that delivers the full 32 mg dose approved for PONV. The ready-to-use, easy-to-administer, innovative IV formulation ensures rapid and consistent exposure in surgery patients.
- Related: Heron Shares Jump After Equity Financing, Q2 Earnings.
- Administered via a single 30-second IV injection, Aponvie reaches drug levels associated with ≥97% receptor occupancy in the brain within five minutes and maintains therapeutic plasma concentrations for at least 48 hours.
- Clinical studies comparing oral aprepitant to the current standard of care, IV ondansetron, demonstrated that aprepitant was more effective.
- Treatment with aprepitant resulted in approximately 50% fewer patients vomiting in the first 24 and 48 hours compared to ondansetron. In clinical studies, Aponvie was well-tolerated and presented a safety profile comparable to oral aprepitant.
- In a 2020 Cochrane meta-analysis, aprepitant was ranked as the most effective drug approved for PONV prophylaxis, the most effective for preventing vomiting in the first 24 hours post-surgery, and the drug with the fewest adverse events.
- Price Action: HRTX shares closed 4.11% lower at $4.67 on Friday.
Crypto Whales Are Loading Up — Are You?
New research shows the biggest crypto buyers are back. And this time? They could hold for the possibility that Bitcoin will surpass $100,000 in 2024. You don’t want to miss the next massive crypto bull run like we saw in 2020 and 2021. To know exactly what’s going on and what to buy… Get Access To Benzinga’s Best Crypto Research and Investments For Only $1.
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