Cytokinetics's Omecamtiv Mecarbil Shows No Effect On Exercise Capacity In Heart Failure Patients


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  • Cytokinetics Incorporated (NASDAQ:CYTKannounced the full results from the METEORIC-HF Phase 3 trial of omecamtiv mecarbil in patients with heart failure with reduced ejection fraction (HFrEF).
  • METEORIC-HF evaluated the effect of treatment with omecamtiv mecarbil compared to placebo on exercise capacity.
  • After 20 weeks of treatment, no effect of omecamtiv mecarbil on exercise capacity was observed versus placebo. 
  • Also See: Cytokinetics Posts Cohort 3 Data From Aficamten Trial In Heart Disease Patients.
  • Patients treated with omecamtiv mecarbil had an average change from baseline in pVO2 of -0.2 ml/kg/min compared to 0.2 ml/kg/min for patients on placebo.
  • No beneficial effect was observed in any of the secondary endpoints, including change in total workload during exercise, change in ventilatory efficiency, and change in daily physical activity.
  • Additional data from GALACTIC-HF were also presented, including a healthcare resource utilization analysis and the effect of omecamtiv mecarbil in hospitalized patients compared to outpatients.
  • In the selected subgroup of the GALACTIC-HF trial, omecamtiv mecarbil was associated with significant reductions in risk of a first heart failure event (relative risk reduction (RRR) 15%, absolute risk reduction (ARR) 3.8, number needed to treat (NNT) 26.2), total HF events (RRR 17%, ARR 6.8, NNT 14.7), and cumulative heart failure events. 
  • The rate of the primary outcome was higher in hospitalized patients in the placebo group (38.3/100 person-years [PY]) than in outpatients (23.1/100 PY) with an adjusted hazard ratio (HR) of 1.21.
  • Price Action: Friday, CYTK shares closed 4.27% higher at $38.38.

27% profit every 20 days?

This is what Nic Chahine averages with his option buys. Not selling covered calls or spreads… BUYING options. Most traders don’t even have a winning percentage of 27% buying options. He has an 83% win rate. Here’s how he does it.


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Posted In: BiotechNewsHealth CareGeneralBriefs