Pfizer Posts Vupanorsen Data From Mid-Stage Cardiovascular Disease Trial


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Pfizer Inc (NYSE:PFE) has provided an update on the Phase 2b study of vupanorsen, investigational antisense therapy for cardiovascular (CV) risk reduction and severe hypertriglyceridemia.

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  • In the dose-ranging study in subjects with elevated non-HDL-C and triglycerides (TG), the study met its primary endpoint, achieving a statistically significant reduction in non-HDL-C at all doses tested at 24 weeks, compared to placebo. 
  • In addition, subjects treated with vupanorsen achieved statistically significant reductions in TG and ANGPTL3 at all dose levels at 24 weeks, compared to placebo.
  • The topline results also showed that vupanorsen dose-dependently lowered its target, angiopoietin-like 3. 
  • Pfizer is continuing to review the findings to determine the next steps regarding future development.
  • The most common adverse events were injection site reactions, which often occurred in the highest vupanorsen dose group. 
  • In November 2019, Pfizer licensed vupanorsen from Ionis Pharmaceuticals Inc (NASDAQ:IONS) in a worldwide exclusive agreement. 
  • Price Action: PFE shares are down 0.45% at $50.85, while IONS stock is down 4.39% at $29 during the market session on the last check Wednesday.

27% profit every 20 days?

This is what Nic Chahine averages with his option buys. Not selling covered calls or spreads… BUYING options. Most traders don’t even have a winning percentage of 27% buying options. He has an 83% win rate. Here’s how he does it.


Posted In: BiotechNewsHealth CareMoversTrading IdeasGeneralBriefsCardiovascular diseasePhase 2 Trial