Exelixis Shares Drop On Mixed Results For Cabometyx Combo In Early Liver Cancer


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  • Exelixis Inc (NASDAQ:EXEL) and Ipsen (OTC:IPSEYhave announced mixed interim results from the COSMIC-312 Phase 3 trial evaluating cabozantinib (Cabometyx) in combination with Roche Holding AG's Tecentriq (atezolizumab) versus Bayer AG's (OTC:BAYRY) sorafenib in previously untreated advanced hepatocellular carcinoma patients.
  • Despite failing a key primary endpoint, the company moves at full speed toward a final readout and a potential label expansion.
  • Cabometyx and Tecentriq reduced the risk of disease progression or death in hepatocellular carcinoma (HCC) patients by 37% compared with sorafenib. 
  • However, it failed to achieve a statistically significant improvement in overall survival at the interim analysis. The company says the probability of hitting the endpoint in time for the final analysis is low.
  • Nevertheless, the COSMIC-312 study will continue as planned to the final analysis in OS, with a readout expected in early 2022.
  • The safety data for combo treatment was consistent with the known safety profiles of Cabometyx and Tecentriq, with no new safety signals identified, Exelixis announced.
  • Price Action: EXEL shares are down 12.7% at $20.45 during the premarket session on the last check Monday.

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Posted In: BiotechNewsHealth CareMoversTrading IdeasGeneralBriefsLiver Cancer