Alkermes Catches A 'Sell' Downgrade On Depression Therapy, M&A Prospects


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Alkermes Plc (NASDAQ:ALKS) has enjoyed a relatively strong Street backing over the last six months despite its nearly 40-percent drop. On Wednesday, though, it caught a downgrade, bringing its ratings mix to six Buys, five Holds and two Sells, according to TipRanks.

The Rating

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Goldman Sachs analyst Terence Flynn cut Alkermes from Neutral to Sell and lowered his price target from $49 to $26.

The Thesis

Flynn removed two key elements from its model: sales of ALKS-5461 for depression and the potential for merger activity.

“We expect FDA to issue a complete response letter (i.e., non-approval) on or before the Jan 31 PDUFA date and we don’t expect Study 217 to be sufficient to address potential FDA issues following the negative Adcom outcome (11/1),” he said of the depression candidate.


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Additionally, channel checks suggest the schizophrenia treatment, ALKS-3831, posts unfavorable metabolic and weight-gain data and will not likely transform treatment.

“The level of SG&A investment ahead of a potential ‘3831 launch is underappreciated (we raise our expenses and are now 9%-15% higher than consensus in 2019-2021),” the analyst wrote in the note.

Flynn would take a more bullish stance on the stock if Alkermes could better differentiate the ALKS-3831 metabolic profile from Zyprexa; secure FDA approval of ALKS-5461; drive leverage in Vivitrol sales; outperform estimates for Aristada; or posts strong activity for ALKS-4230 in cancer treatment.

Price Action

At time of publication, Alkermes shares were down 3.4 percent at $30.72.

Related Links:

FDA Committees' Unfavorable Ruling Depresses Alkermes Shares

Alkermes Falls 20% After FDA Refusal To File Letter


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Posted In: Analyst ColorDowngradesPrice TargetTop StoriesAnalyst RatingsGoldman SachsTerence Flynn