Clovis Oncology Targeted Cancer Radiation Therapy Shows Greater Tumor Inhibition


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Clovis Oncology Inc (NASDAQ:CLVS) announced two abstracts featuring non-clinical data from studies evaluating FAP-2286 and Rubraca and a Trial-in-Progress poster detailing the Phase 1 portion of the LuMIERE study.

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  • In a new non-clinical data analysis, FAP-2286 demonstrated a potent human fibroblast activation protein (FAP) affinity by biochemical and cell-based assays. 
  • Additionally, lutetium-177 (177Lu)-FAP-2286 showed longer tumor retention, resulting in more significant tumor inhibition than lutetium-177 (177Lu)-FAPI-46, a FAP-targeted radiotracer developed for therapeutic applications at the University of Heidelberg, Germany.
  • Approximately 50 patients will be enrolled in the Phase 1 portion of LuMIERE trial, which is currently enrolling patients with advanced solid tumors. 
  • Related: Clovis Oncology's Rubraca Significantly Improves PFS In Ovarian Cancer Regardless Of Biomarker Status.
  • The Phase 1 portion is evaluating the safety of 177Lu-FAP-2286 and will identify the recommended Phase 2 dose and schedule. 
  • Phase 2 expansion cohorts in multiple tumor types are planned for later in 2022.
  • Separately, non-clinical data evaluating Rubraca efficacy in a panel of tumors with deleterious alterations in a core group of non-BRCA HRR genes showed responses similar to the efficacy observed in BRCA1/2-altered models.
  • Price Action: CLVS shares are down 1.85% at $2.65 during the market session on the last check Friday.

27% profit every 20 days?

This is what Nic Chahine averages with his option buys. Not selling covered calls or spreads… BUYING options. Most traders don’t even have a winning percentage of 27% buying options. He has an 83% win rate. Here’s how he does it.


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