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Regulus Therapeutics Inc (NASDAQ:RGLS) has initiated studies to evaluate a library of oligonucleotides to block miR-155 for Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease) under a collaboration agreement with Harvard's Brigham and Women's Hospital (BWH).
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- The agreement, effective since September 2021, encompasses the investigation of the biologic effects of miR-155 inhibitors in both in vitro and in vivo models of ALS.
- Results from these initial studies will guide future experiments' design in additional animal models of the disease and characterize their properties.
- Preliminary data from the studies are expected in 2H of 2022.
- In animal models of ALS, miR-155 was found upregulated in microglia and associated with disease progression. Notably, miR-155 was also elevated in the spinal cord of patients with ALS.
- Anti-miR-155 treatment suppressed disease-associated cytotoxic microglia, and resulted in robust improvement in clinically relevant disease endpoints, including prolongation of survival.
- Price Action: RGLS shares are up 1.08% at $0.29 during the market session on the last check Thursday.
Crypto Whales Are Loading Up — Are You?
New research shows the biggest crypto buyers are back. And this time? They could hold for the possibility that Bitcoin will surpass $100,000 in 2024. You don’t want to miss the next massive crypto bull run like we saw in 2020 and 2021. To know exactly what’s going on and what to buy… Get Access To Benzinga’s Best Crypto Research and Investments For Only $1.