AstraZeneca Pulls Plug On MCL-1 Cancer Drug Trial


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  • AstraZeneca Plc (NASDAQ:AZN) has paused an active Phase 1 trial of AZD5991, a direct inhibitor of MCL-1, citing a potential safety issue.
  • Two years ago, the FDA hit Amgen Inc (NASDAQ:AMGN) with a clinical hold on its MCL-1 inhibitor AMG 397 following signs of cardiac toxicity.
  • AstraZeneca's AZD5991 belongs to the same class therapy.
  • The trial suspension, noted on ClinicalTrials.gov, came on October 19: "The study has been put on hold to allow further evaluation of safety-related information," the update said.
  • AstraZeneca planned to recruit 144 patients for the study, slated to complete in March 2023. 
  • The trial was assessing AZD5991, either alone or combined with AbbVie Inc (NYSE:ABBV) / Roche Holding AG's (OTC:RHHBY) Venetoclax in relapsed or refractory acute myeloid leukemia (AML). 
  • The drug works by targeting apoptosis, the process of programmed cell death, specifically in blood cancer.
  • Price Action: AZN shares are up 0.71% at $60.6 during the market session on the last check Wednesday.

Buy at this blue line for a shot at trading profitably

There are so many indicators out there on when to buy and sell. Nic uses none. He looks at a chart and buys when a stock “pushes” off this blue line. What blue line? Find out on the next page. It’ll change how you make money from stocks. Click here for the details.


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Posted In: BiotechNewsHealth CareGeneralacute myeloid leukemiaBriefsPhase 1 Trial