AstraZeneca's Two Asthma Trials Meet Primary Endpoints


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  • Avillion LLP announces positive topline results from the MANDALA and DENALI Phase 3 trials of PT027 in asthma patients.
  • PT027 is an inhaled, fixed-dose combination of albuterol and budesonide developed by AstraZeneca Plc (NASDAQ:AZN) and Avillion.
  • The trials met all primary endpoints at both 180/160mcg and 180/80mcg doses and demonstrated statistically significant benefits versus individual albuterol and budesonide components.
  • The PT027 clinical co-development program was funded by Blackstone Life SciencesRoyalty Pharma (NASDAQ:RPRX), and Abingworth.
  • The MANDALA trial demonstrated statistically significant and clinically meaningful reductions in the risk of severe exacerbations compared to albuterol when used as a rescue medicine in response to symptoms. 
  • The trial included 3,132 patients taking maintenance inhaled corticosteroid (ICS) with or without additional controller medicines.
  • The DENALI trial showed a statistically significant improvement in lung function compared to the individual components and placebo. 
  • The trial included 1,001 patients previously treated either with a SABA as needed alone or in addition to low-dose maintenance ICS therapy.
  • The safety and tolerability of PT027 in both trials were consistent with the known profiles of the components.
  • Detailed data from the trial will be presented at an upcoming medical meeting.
  • Price Action: AZN shares are down 0.54% at $56.76 during the premarket session on the last check Thursday.

27% profit every 20 days?

This is what Nic Chahine averages with his option buys. Not selling covered calls or spreads… BUYING options. Most traders don’t even have a winning percentage of 27% buying options. He has an 83% win rate. Here’s how he does it.


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Posted In: BiotechNewsHealth CareGeneralasthmaBriefsPhase 3 Trial