Yet Another Biogen's Retinal Disease Gene Therapy Fails In Late-Stage Study


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  • While basking in the glow of the approval for its Alzheimer’s treatment, Biogen Inc (NASDAQ:BIIB) announced that a gene therapy candidate for eye disease failed a late-stage clinical trial, yet again.
  • The company announced topline results from Phase 3 STAR study of timrepigene emparvovec (BIIB111/AAV2-REP1) for choroideremia, a rare inherited retinal disease that results in progressive vision loss.
  • The treatment failed the primary endpoint, the proportion of participants with more than 15 letter improvement from baseline in best-corrected visual acuity (BCVA) at Month 12 — as well as all key secondaries.
  • The safety results were consistent with previous studies. Phase 3 involved 169 men with a confirmed diagnosis of choroideremia.
  • Biogen will evaluate the full dataset from timrepigene’s Star study as they consider the next steps for the program. Full results will be presented at a future scientific forum.
  • Just a month back, cotoretigene toliparvovec gene therapy in X-linked retinitis pigmentosa failed on the primary endpoint but did seem to improve vision in low light conditions.
  • Both gene therapies came out of Biogen’s $877 million deal for Nightstar Therapeutics.
  • Price Action: BIIB shares closed at $406.14 on Monday.

27% profits every 20 days?

This is what Nic Chahine averages with his options buys. Not selling covered calls or spreads... BUYING options. Most traders don't even have a winning percentage of 27% buying options. He has an 83% win rate. Here's how he does it.


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Posted In: BiotechNewsHealth CareFDAGeneralBriefsEye Diseasegene therapyPhase 3 Trial