Neurocrine/Takeda's Luvadaxistat Fails To Improve Schizophrenia Symptom Severity


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Neurocrine Biosciences Inc (NASDAQ: NBIXannounces topline data from Phase 2 INTERACT study evaluating luvadaxistat (NBI-1065844/TAK-831) for the treatment of negative symptoms and cognitive impairment associated with schizophrenia.

  • Luvadaxistat is an oral, selective inhibitor with a high binding affinity to d-amino acid oxidase. It targets glutamate, an abundant neurotransmitter in the brain. 
  • The trial did not meet its primary endpoint as measured by the change from baseline on the PANSS NSFS (score used to assess schizophrenia symptom severity) at Day 84.
  • Luvadaxistat met secondary endpoints of cognitive assessment.
  • Takeda Pharmaceutical Co Ltd (NYSE: TAKgranted an exclusive license to Neurocrine Biosciences for seven pipeline programs, including luvadaxistat, in June last year.
  • The results from the study are being evaluated to determine the next steps for development activities.
  • Price Action: TAK shares are up 1.88% at $17.30, while NBIX shares are down by 5.03% at $103.93 in the pre-market session on the last check Tuesday.

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Posted In: BiotechNewsHealth CareFDAGeneralPhase 2 TrialSchizophrenia