AstraZeneca/Amgen's Tezepelumab Reduces Asthma Exacerbations, Phase 3 Trial Shows


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  • AstraZeneca Plc (NASDAQ: AZN) and its partner Amgen Inc (NASDAQ: AMGN) have announced positive results from NAVIGATOR Phase 3 trial evaluating tezepelumab in severe asthma.
  • Results were presented at the American Academy of Asthma Allergy & Immunology Annual Meeting.
  • Tezepelumab achieved a 56% reduction in exacerbation rate over 52 weeks in the overall patient population, compared to placebo when added to standard of care.
  • In a pre-specified analysis of the subgroup of patients with baseline eosinophil counts less than 300 cells per microliter, tezepelumab achieved a 41% reduction in exacerbation rate.
  • 39% and 70% reduction in patients with baseline eosinophil counts less than 150 and greater than or equal to 300 cells per microliter, respectively.
  • No clinically meaningful differences in safety results between the tezepelumab and placebo groups were observed.
  • The most frequently reported adverse events were nasopharyngitis, upper respiratory tract infection, and headache.
  • Tezepelumab blocks the action of thymic stromal lymphopoietin, an epithelial cytokine that plays a key role across the spectrum of asthma inflammation.
  • Price Action: AZN and AMGN shares are down 0.9% in market trading hours on the last check Friday.

27% profits every 20 days?

This is what Nic Chahine averages with his options buys. Not selling covered calls or spreads... BUYING options. Most traders don't even have a winning percentage of 27% buying options. He has an 83% win rate. Here's how he does it.


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Posted In: BiotechNewsHealth CareFDAGeneralasthmaPhase 3 Trial