Benzinga's Top #PreMarket Losers

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Alcobra Ltd (NASDAQ: ADHD) shares declined 13.35 percent to $7.27 in pre-market trading after the company reported results from Phase 2 trial of MDX for Fragile X syndrome. The company said study did not meet primary endpoint of change on ADHD RS-IV inattentive subscale.

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FireEye Inc (NASDAQ: FEYE) fell 3.36 percent to $51.05 in pre-market trading after gaining 0.76 percent on Tuesday. BIND Therapeutics Inc (NASDAQ: BIND) shares fell 3.31 percent to $5.85 in pre-market trading after rising 3.24 percent on Tuesday.

Fortinet Inc (NASDAQ: FTNT) shares tumbled 3.29 percent to $41.79 in pre-market trading. Baird downgraded Fortinet from Neutral to Underperform. Compugen Ltd. (USA) (NASDAQ: CGEN) shares dropped 2.38 percent to $7.37 in pre-market. Compugen shares have declined 19.51 percent over the past 52 weeks, while the S&P 500 index has gained 8.40 percent in the same period.