Intra-Cellular Therapies Soars To Multiyear High Following FDA Nod For Schizophrenia Drug


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Shares of small-cap biopharma Intra-Cellular Therapies Inc (NASDAQ:ITCI) were nearly doubling Monday after a binary event panned out in favor of the company.

The shares are trading at their highest level since late 2016.

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FDA Approves Lumateperone 

Intra-Cellular said the FDA has approved its lumateperone for treating schizophrenia.

Lumateperone, which goes by the trade name Caplyta, is an oral, once-daily medicine. Its efficacy is mediated through a combination of antagonist activity at central serotonin 5-HT2A receptors and postsynaptic antagonist activity at central dopamine receptors.

Intra-Cellular Developing Drug For Other Indications

Schizophrenia, a chronic disease often accompanied by depression and gradual deterioration of social functioning and cognitive ability, affects about 2.4 million adults in the U.S.


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Most patients often discontinue treatment due to side effects such as weight gain and movement disorders.

"We believe Caplyta provides health care providers a new, safe and effective treatment option to help the millions of adult patients with schizophrenia," CEO Dr. Sharon Mates said in a statement.

Intra-Cellular is also developing Caplyta for bipolar depression; behavioral disturbances in patients with dementia, including Alzheimer's disease; depression and other neuropsychiatric and neurological disorders.

The company said it expects to commercially launch Caplyta late in the first quarter of 2020.

Intra-Cellular shares were jumping 181.03% to $34.96 at the time of publication. 

Related Links:

The Week Ahead In Biotech: Correvio, Intra-Cellular Therapies Await FDA Decisions

Minerva Neurosciences Shelves Depression Drug Study After Failed Mid-Stage Trial


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