Savolitinib, AstraZeneca Complete Enrolment for Phase II Clinical Trial in Papillary Renal Cell Carcinoma


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Hutchison China MediTech Limited (OTC: HNCMF) today announces that Hutchison MediPharma Limited, its drug R&D subsidiary, and AstraZeneca AB (NYSE: AZN) have completed enrolment in a global Phase II study of savolitinib (AZD6094), a potent and highly selective mesenchymal epithelial transition factor ("c-Met") inhibitor.  This is a Phase II study to evaluate the efficacy and safety of savolitinib monotherapy (600 mg once daily) in papillary renal cell carcinoma ("PRCC") in the United States, Canada and Europe.  PRCC represents about 14% of all new cases of kidney cancer.  Savolitinib is a potential global first-in-class inhibitor of c-Met, receptor tyrosine kinase, an enzyme which exhibits aberrant behaviour (e.g. gene amplification, over-expression and mutation) in many types of solid tumours.  Savolitinib was developed as a potent and highly selective oral c-Met inhibitor that was designed to address renal toxicity, the primary issue that has to-date prevented other selective c-Met inhibitors from gaining regulatory approval. In Phase I/Ib clinical studies, savolitinib has shown promising signs of clinical efficacy, causing tumour size reduction, in c-Met aberrant patients in PRCC, non-small cell lung cancer, colorectal cancer and gastric cancer.This Phase II study is an open-label, single-arm, multicentre study designed

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27% profit every 20 days?

This is what Nic Chahine averages with his option buys. Not selling covered calls or spreads… BUYING options. Most traders don’t even have a winning percentage of 27% buying options. He has an 83% win rate. Here’s how he does it.


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