MediciNova Announces First Advanced ALS Patient Using Non-Invasive Ventilation Support Enrolled in Phase 2 Clinical Trial of MN-166

MediciNova, Inc. (NASDAQ: MNOV) today announced that the first advanced ALS patient, using non-invasive ventilation (NIV), has enrolled in the Phase 2 clinical trial evaluating MN-166 (ibudilast) in both early and advanced stage ALS. MediciNova amended the protocol to expand its recruitment to include advanced ALS patients in the trial, and this amendment was approved by FDA (U.S. Food and Drug Administration). The amended protocol now plans enrollment of 60 advanced ALS patients with NIV support in the study in addition to 60 patients without NIV support. Dr. Benjamin Rix Brooks, Director, Carolinas HealthCare System's Neuromuscular/ALS-MDA Center, is the Principal Investigator of the study. Yuichi Iwaki, MD, PhD, President and Chief Executive Officer of MediciNova, Inc., commented, "We are very pleased to have successfully completed the FDA review period, which allows us to enroll the first advanced ALS patient with NIV support. The safety and efficacy data from advanced ALS patients will be important for our development efforts in ALS and is complementary to the ongoing study that is enrolling ALS See full press release